Asked whether Kittle would play in Week 1, 49ers offensive coordinator Klay Kubiak said, “We have two more practices, but Kittle looks good.” That was not as explicit as defensive coordinator Raheem Morris’ quote on Nick Bosa’s expected status just minutes earlier, but it certainly seems to confirm mounting reports that Kittle is on track to suit up for Week 1. Kubiak added at the end of his response that Kittle’s “workload will be determined,” also reinforcing earlier reports that the team was likely to monitor his snap rate closely. Fantasy managers are likely better off taking a wait-and-see approach with Kittle until he has proven to be capable of a normal workload.

During a media sessions late Monday, Morris was asked if Bosa would be able to go in Week 1 against the Rams, to which he responded, “Oh, he’s going out there. He’s going.” There’s no room left for interpretation about that quote, meaning Bosa is expected to make his return to the field after tearing his ACL in Week 3 of the 2025 season. Don’t expect a normal allotment of snaps in his first game in almost a calendar year, but the veteran pass-rusher can still make a significant impact when on the field. IDP managers will want to confirm his status on the team’s injury report Tuesday before making plans to insert him into Week 1 lineups.

It was the second straight day with the same level of participation for the second-year receiver, who could be headed for a game-day injury designation for the team’s season opener. We were kept in the dark regarding Horton’s ailment after he missed the final three weeks of camp, with a hamstring injury now labeled as the cause. Although Jake Bobo’s season-ending ACL tear all but guaranteed Horton a spot on game-day rosters, he remains unlikely to contribute meaningful counting stats playing behind Jaxon Smith-Njigba, Rashid Shaheed, and Cooper Kupp. Second-year undrafted free agent Montorie Foster Jr would be in line to serve as the team’s fourth receiver on Wednesday should Horton be unable to go.

It’s the second straight missed practice for Okada as he tends to a hamstring injury, while fellow starting safety Nick Emmanwori (ankle) is thought to be doubtful to suit up against the Patriots Wednesday, per those close to the team. The team’s final injury report of their Week 1 preparation will be released Tuesday, upon which we’ll receive final game designations. Keep a close eye on the transaction reports from Seattle to gauge the expected level of health of both players. Considering the Seahawks carried only three safeties on their initial 53-man roster, any practice squad elevations from the secondary could signal expected absences from one, or both, players.

Henderson traveled with the team to Seattle as it prepares for Wednesday’s game against the Seahawks, but he was unable to get on the practice field. That’s now back-to-back DNPs for Henderson, who is trending toward missing the season opener. Unless he can log a limited practice on Tuesday, it wouldn’t be surprising if Henderson was ruled out well before Wednesday’s game, paving the way for Rhamondre Stevenson to have a busy Week 1 in this rematch between last year’s Super Bowl contenders.

This, of course, is in reference to the civil lawsuit that was filed against Nacua that alleges he bit a woman and made an “unprovoked antisemitic sentiment.” The Rams receiver avoided being placed on the commissioner’s exempt list and will travel with the team to Australia to play in their season opener against the 49ers. Nacua has been dealing with a psoas injury since August, but head coach Sean McVay said they expect him to play in Week 1. Nacua profiles as a high-end WR1 against a familiar foe in the Niners.

Pierce missed most of training camp while recovering from offseason ankle surgery, but the fifth-year speedster is expected to be on the field when the Colts take on the Ravens in the season opener. ESPN’s Stephen Holder noted that “it’s very possible” some of Pierce’s workload will be split between Keenan Allen and Ashton Dulin as he continues to ramp up after an extended absence, but Pierce will be on the field in some capacity on Sunday. Unfortunately, this makes him a risky bet for fantasy purposes unless Steichen can alleviate any concerns about Pierce being on a pitch count to start the season.

Tee Higgins (heel contusion) was also spotted at practice after both players were said to be limited participants last week. The Bengals won’t release their first official injury report of the week until Wednesday, but it doesn’t sound like either Chase or Higgins is at risk of missing Week 1’s game against the Buccaneers. As usual, Chase profiles as a high-end fantasy WR1, while Higgins should be viewed more as a WR2 with WR1 upside in any given week.

Kittle was on the field on Monday when the Niners took the field to begin prepping for their Week 1 opener against the Rams in Australia. The veteran tight end has long been expected to have a shot to play in Thursday’s game, so the fact that he was on the field doesn’t come as much of a surprise. Kittle was able to log a few practices last week, but could be on a bit of a pitch count in his first game since suffering a torn Achilles in mid-January. Assuming he is limited in some capacity, Kittle should be viewed as a boom/bust TE1 for fantasy purposes.

Despite an up-and-down training camp, Tagovailoa will get the nod as the starter when the Falcons kick off the season on Sunday against the Steelers. Given the fact that Michael Penix Jr. (knee) was still limited at the start of camp, Tagovailoa had long been assumed to have the inside edge on the QB1 job at the start of camp, but Penix was still given a shot to compete for the job despite not being cleared for 11-on-11 practice until August 22. Tagovailoa shouldn’t be counted on in standard 1QB leagues at this point, and fantasy managers looking to add him in 2QB and superflex leagues shouldn’t view him as a long-term solution. It would not be at all surprising if we saw both Tagovailoa and Penix start multiple games for the Falcons this season, with rookie UDFA Jack Stand also being a dark horse to see snaps at some point in the season after an impressive training camp and preseason.